査読有り論文・総説 Peer-reviewed articles and reviews

(*corresponding author)


70. Zhang K, Zhu Y, Zhu Y, Wu S, Liu H, Zhang W, Xu C, Zhang H, Hayashi T, Tian M. Molecular, Functional, and Structural Imaging of Major Depressive Disorder. Neuroscience Bulletin 2016 32(3), 273-285.

69. Shingaki T, Katayama Y, Nakaoka T, Irie S, Onoe K, Okauchi T, Hayashinaka E, Yamaguchi M, Tanki N, Ose T, Hayashi T, Wada Y, Furubayashi T, Cui Y, Sakane T, Watanabe Y. Visualization of drug translocation in the nasal cavity and pharmacokinetic analysis on nasal drug absorption using positron emission tomography in the rat. Eur J Pharm Biopharm. 2015 99:45-53.

68. Murata Y*, Higo N, Hayashi T, Nishimura Y, Sugiyama Y, Oishi T, Tsukada H, Isa T, Onoe H. Temporal plasticity involved in recovery from manual dexterity deficit after motor cortex lesion in macaque monkeys. J Neurosci. 2015 Jan 7;35(1):84–95.

67. Takenobu Y, Hayashi T*, Moriwaki H, Nagatsuka K, Naritomi H, Fukuyama H. Motor recovery and microstructural change in rubro-spinal tract in subcortical stroke. Neuroimage: Clinical, 2014;4,201-208. <プレスリリース> <PDF>

66. Hatano K*, Terao T, Hoaki N, Kohno K, Araki Y, Mizokami Y, Kodama K, Harada M, Fujiki M, Shimomura T, Hayashi T. Association between affective temperaments and regional gray matter volume in healthy subjects. J Affect Disord. 2014 Feb;155:169-73. doi: 10.1016/j.jad.2013.10.045. Epub 2013 Oct 30.

65. Morizane A, Doi D, Kikuchi T, Okita K, Hotta A, Kawasaki T, Hayashi T, Onoe H, Shiina T, Yamanaka S, Takahashi J*. Direct Comparison of Autologous and Allogeneic Transplantation of iPSC-Derived Neural Cells in the Brain of a Nonhuman Primate. Stem Cell Reports. 2013;1(4):283–92.

64. Hayashi T* & Onoe H. Neuroimaging for optimization of stem cell therapy in Parkinson’s disease [Editorial]. Expert Opin Biol Ther 2013;13(12):1631-1638 Epub 2013 Sep 8.

63. Hayashi T*, Ko JH, Strafella AP, Dagher A*. Dorsolateral prefrontal and orbitofronral cortex interactions during self-control of cigarette craving. Proc Natl Acad Sci U S A. 2013 Mar 12 110(11):4422-7, Epub 2013 Jan 28
<プレスリリース> <press release-RIKEN> <press release-McGill> <RIKEN highlights> <PNAS highlight> <PNAS commentary> <AFP> <Voice of Russia>

62. Hayashi T*, Shimazawa M, Watabe H, Ose T, Inokuchi Y, Ito Y, Yamanaka H, Urayama S, Watanabe Y, Hara H, Onoe H. Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma. Molecular Neurodegeneration. 2013 Jan 18;8(1):4.

61. Hayashi T*, Wakao S, Kitada M, Ose T, Watabe H, Kuroda Y, Mitsunaga K, Matsuse D, Shigemoto T, Ito A, Ikeda H, Fukuyama H, Onoe H, Tabata Y, Dezawa M*. Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques. J. Clin. Invest. 2013 Jan 2;123(1):272–84.
<プレスリリース> <RIKEN highlights> <Nat Rev Neurol highlight> <LA Times>

60. Kudomi N, Hirano Y, Koshino K, Hayashi T, Watabe H, Fukushima K, Moriwaki H, Teramoto N, Iihara K, Iida H. Rapid quantitative CBF and CMRO2 measurements from a single PET scan with sequential administration of dual 15O-labeled tracers. J. Cereb. Blood Flow Metab. 2013 33(3):440-8, Epub 2012 Dec 12;  

59. Enmi J-I, Kudomi N, Hayashi T, Yamamoto A, Iguchi S, Moriguchi T, Hori Y, Koshino K, Zeniya T, Jon Shah N, Yamada N, Iida H. Quantitative assessment of regional cerebral blood flow by dynamic susceptibility contrast-enhanced MRI, without the need for arterial blood signals. Phys Med Biol. 2012 Dec 7;57(23):7873–92.

58. Yokoyama C, Kawasaki A, Hayashi T, Onoe H. Linkage between the midline cortical serotonergic system and social behavior traits: positron emission tomography studies of common marmosets. Cereb. Cortex. 2013 23(9):2136-45, Epub 2012 Jul 12

57. Ose T, Watabe H, Hayashi T, Kudomi N, Hikake M, Fukuda H, Teramoto N, Watanabe Y, Onoe H, Iida H. Quantification of regional cerebral blood flow in rats using an arteriovenous shunt and micro-PET. Nucl. Med. Biol. 2012 Jul;39(5):730–41.

56. Koshino K, Watabe H, Enmi J, Hirano Y, Zeniya T, Hasegawa S, Hayashi T, Miyagawa S, Sawa Y, Hatazawa J, Iida H. Effects of patient movement on measurements of myocardial blood flow and viability in resting 15O-water PET studies. J Nucl Cardiol. 2012 Jun;19(3):524–33.

55. Doi D, Morizane A, Kikuchi T, Onoe H, Hayashi T, Kawasaki T, Motono M, Sasai Y, Saiki H, Gomi M, Yoshikawa T, Hayashi H, Shinoyama M, Refaat MM, Suemori H, Miyamoto S, Takahashi J. Prolonged maturation culture favors a reduction in the tumorigenicity and the dopaminergic function of human ESC-derived neural cells in a primate model of Parkinson’s disease. Stem Cells. 2012 May;30(5):935–45.

54. Shimazawa M, Ito Y, Inokuchi Y, Yamanaka H, Nakanishi T, Hayashi T, Ji B, Higuchi M, Suhara T, Imamura K, Araie M, Watanabe Y, Onoe H, Hara H. An alteration in the lateral geniculate nucleus of experimental glaucoma monkeys: in vivo positron emission tomography imaging of glial activation. PLoS ONE. 2012;7(1):e30526.

53. Zeniya T, Watabe H, Hayashi T, Ose T, Myojin K, Taguchi A, Yamamoto A, Teramoto N, Kanagawa M, Yamamichi Y, Iida H. Three-dimensional quantitation of regional cerebral blood flow in mice using a high-resolution pinhole SPECT system and 123I-iodoamphetamine. Nucl. Med. Biol. 2011 Nov;38(8):1157–64.

52. Matsubara K, Watabe H, Kumakura Y, Hayashi T, Endres CJ, Minato K, Iida H. Sensitivity of kinetic macro parameters to changes in dopamine synthesis, storage, and metabolism: a simulation study for [18F]FDOPA PET by a model with detailed dopamine pathway. Synapse. 2011 Aug;65(8):751–62.

51. Kikuchi T, Morizane A, Doi D, Onoe H, Hayashi T, Kawasaki T, Saiki H, Miyamoto S, Takahashi J. Survival of human induced pluripotent stem cell–derived midbrain dopaminergic neurons in the brain of a primate model of Parkinson’s disease. Journal of Parkinson’s disease. 2011 Jan 1;1(4):395–412.

50. Saiki H, Hayashi T, Takahashi R, Takahashi J. Objective and quantitative evaluation of motor function in a monkey model of Parkinson’s disease. J. Neurosci. Methods. 2010 Jul 15;190(2):198–204.

49. Mizuma H, Shukuri M, Hayashi T, Watanabe Y, Onoe H. Establishment of in vivo brain imaging method in conscious mice. J Nucl Med. 2010 Jul;51(7):1068–75.

48. Wakao S, Hayashi T, Kitada M, Kohama M, Matsue D, Teramoto N, Ose T, Itokazu Y, Koshino K, Watabe H, Iida H, Takamoto T, Tabata Y, Dezawa M. Long-term observation of auto-cell transplantation in non-human primate reveals safety and efficiency of bone marrow stromal cell-derived Schwann cells in peripheral nerve regeneration. Exp Neurol. 2010 Jun;223(2):537–47.

47. Kudomi N, Watabe H, Hayashi T, Oka H, Miyake Y, Iida H. Optimization of transmission scan duration for 15O PET study with sequential dual tracer administration using N-index. Ann Nucl Med. 2010 Jun;24(5):413–20.

46. Ikoma Y, Watabe H, Hayashi T, Miyake Y, Teramoto N, Minato K, Iida H. Measurement of density and affinity for dopamine D2 receptors by a single positron emission tomography scan with multiple injections of [11C]raclopride. J Cereb. Blood Flow Metab. 2010 Mar;30(3):663–73.

45. Temma T, Iida H, Hayashi T, Teramoto N, Ohta Y, Kudomi N, Watabe H, Saji H, Magata Y. Quantification of regional myocardial oxygen metabolism in normal pigs using positron emission tomography with injectable 15O-O2. Eur J Nucl Med Mol Imaging. 2010 Feb;37(2):377–85.

44. Koshino K, Watabe H, Hasegawa S, Hayashi T, Hatazawa J, Iida H. Development of motion correction technique for cardiac 15O-water PET study using an optical motion tracking system. Ann Nucl Med. 2010 Jan;24(1):1–11.


43. Yamamoto A, Sato H, Enmi J, Ishida K, Ose T, Kimura A, Fujiwara H, Watabe H, Hayashi T, Iida H. Use of a clinical MRI scanner for preclinical research on rats. Radiol Phys Technol. 2009 Jan;2(1):13–21.

42. Kudomi N, Hayashi T, Watabe H, Teramoto N, Piao R, Ose T, Koshino K, Ohta Y, Iida H. A physiologic model for recirculation water correction in CMRO2 assessment with 15O2 inhalation PET. J Cereb Blood Flow Metab. 2009;29(2):355–64.

41. Iwanishi K, Watabe H, Hayashi T, Miyake Y, Minato K, Iida H. Influence of residual oxygen-15-labeled carbon monoxide radioactivity on cerebral blood flow and oxygen extraction fraction in a dual-tracer autoradiographic method. Ann Nucl Med. 2009;23(4):363–71.

40. Iwanishi K, Watabe H, Fujisaki H, Hayashi T, Miyake Y, Minato K, Naganuma M, Uehara T, Yokota C, Moriwaki H, Kajimoto K, Fukushima K, Minematsu K, Iida H. Evaluation of utility of asymmetric index for count-based oxygen extraction fraction on dual-tracer autoradiographic method for chronic unilateral brain infarction. Ann Nucl Med. 2009;23(6):533–9.

39. Ikoma Y, Watabe H, Hayashi T, Miyake Y, Teramoto N, Minato K, Iida H. Quantitative evaluation of changes in binding potential with a simplified reference tissue model and multiple injections of [11C]raclopride. Neuroimage. 2009;47(4):1639–48.

38. Dagher A, Tannenbaum B, Hayashi T, Pruessner JC, McBride D. An acute psychosocial stress enhances the neural response to smoking cues. Brain Res. 2009;1293:40–8.

37. Sato H, Enmi J, Teramoto N, Hayashi T, Yamamoto A, Tsuji T, Naito H, Iida H. Comparison of Gd-DTPA-induced signal enhancements in rat brain C6 glioma among different pulse sequences in 3-Tesla magnetic resonance imaging. Acta Radiol. 2008;49(2):172–9.

36. Iida H, Eberl S, Kim KM, Tamura Y, Ono Y, Nakazawa M, Sohlberg A, Zeniya T, Hayashi T, Watabe H. Absolute quantitation of myocardial blood flow with 201Tl and dynamic SPECT in canine: optimisation and validation of kinetic modelling. Eur J Nucl Med Mol Imaging. 2008;35(5):896–905.

35. Shimamura M, Sato N, Sata M, Kurinami H, Takeuchi D, Wakayama K, Hayashi T, Iida H, Morishita R. Delayed postischemic treatment with fluvastatin improved cognitive impairment after stroke in rats. Stroke. 2007 Dec;38(12):3251–8.

34. Kudomi N, Watabe H, Hayashi T, Iida H. Separation of input function for rapid measurement of quantitative CMRO2 and CBF in a single PET scan with a dual tracer administration method. Phys Med Biol. 2007;52(7):1893–908.

33. Zeniya T, Watabe H, Aoi T, Kim KM, Teramoto N, Takeno T, Ohta Y, Hayashi T, Mashino H, Ota T, Yamamoto S, Iida H. Use of a compact pixellated gamma camera for small animal pinhole SPECT imaging. Ann Nucl Med,. 2006;20 (6):pp. 409–16.

32. Yakushiji Y, Otsubo R, Hayashi T, Fukuchi K, Yamada N, Hasegawa Y, Minematsu K. Glucose utilization in the inferior cerebellar vermis and ocular myoclonus. Neurology. 2006;67(1):131–3.

31. Ugawa Y, Okabe S, Hayashi T, Ohnishi T, Nonaka Y. Repetitive transcranial magnetic stimulation (rTMS) in monkeys. Suppl Clin Neurophysiol. 2006;59:173–81.

30. Shimamura M, Sato N, Waguri S, Uchiyama Y, Hayashi T, Iida H, Nakamura T, Ogihara T, Kaneda Y, Morishita R. Gene transfer of hepatocyte growth factor gene improves learning and memory in the chronic stage of cerebral infarction. Hypertension. 2006;47(4):742–51.

29. Kim KM, Watabe H, Hayashi T, Hayashida K, Katafuchi T, Enomoto N, Ogura T, Shidahara M, Takikawa S, Eberl S, Nakazawa M, Iida H. Quantitative mapping of basal and vasareactive cerebral blood flow using split-dose 123I-iodoamphetamine and single photon emission computed tomography. Neuroimage. 2006;33(4):1126–35.

28. Watabe H, Jino H, Kawachi N, Teramoto N, Hayashi T, Ohta Y, Iida H. Parametric imaging of myocardial blood flow with 15O-water and PET using the basis function method. J Nucl Med. 2005;46(7):1219–24.

27. Takagi Y, Takahashi J, Saiki H, Morizane A, Hayashi T, Kishi Y, Fukuda H, Okamoto Y, Koyanagi M, Ideguchi M, Hayashi H, Imazato T, Kawasaki H, Suemori H, Omachi S, Iida H, Itoh N, Nakatsuji N, Sasai Y, Hashimoto N. Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. J Clin Invest. 2005;115:102–9.

26. Ogawa M, Watabe H, Teramoto N, Miyake Y, Hayashi T, Iida H, Murata T, Magata Y. Understanding of cerebral energy metabolism by dynamic living brain slice imaging system with [18F]FDG. Neurosci Res. 2005;52(4):357–61.

25. Kudomi N, Hayashi T, Teramoto N, Watabe H, Kawachi N, Ohta Y, Kim KM, Iida H. Rapid quantitative measurement of CMRO2 and CBF by dual administration of 15O-labeled oxygen and water during a single PET scan-a validation study and error analysis in anesthetized monkeys. J Cereb Blood Flow Metab. 2005;25(9):1209–24.

24. Zeniya T, Watabe H, Aoi T, Kim KM, Teramoto N, Hayashi T, Sohlberg A, Kudo H, Iida H. A new reconstruction strategy for image improvement in pinhole SPECT. Eur J Nucl Med Mol Imaging. 2004;31(8):1166–72.

23. Taguchi A, Matsuyama T, Moriwaki H, Hayashi T, Hayashida K, Nagatsuka K, Todo K, Mori K, Stern DM, Soma T, Naritomi H. Circulating CD34-positive cells provide an index of cerebrovascular function. Circulation. 2004;109(24):2972–5.

22. Sato H, Enmi J, Hayashi T, Takei N, Iwadate Y, Abe S, Teramoto N, Kawachi N, Hattori M, Watabe H, Sawada T, Uchiyama K, Tsukamoto T, Nagasawa K, Iida H. Development of a hyperpolarized 129Xe system on 3T for the rat lungs. Magn Reson Med Sci. 2004;3(1):1–9.

21. Ohnishi T, Hayashi T, Okabe S, Nonaka I, Matsuda H, Iida H, Imabayashi E, Watabe H, Miyake Y, Ogawa M, Teramoto N, Ohta Y, Ejima N, Sawada T, Ugawa Y. Endogenous dopamine release induced by repetitive transcranial magnetic stimulation over the primary motor cortex: an [11C]raclopride positron emission tomography study in anesthetized macaque monkeys. Biol Psychiatry. 2004;55(5):484–9.

20. Inoue M, Katsumi Y, Hayashi T, Mukai T, Ishizu K, Hashikawa K, Saji H, Fukuyama H. Sensory stimulation accelerates dopamine release in the basal ganglia. Brain Res. 2004;1026(2):179–84.

19. Hayashi T, Ohnishi T, Okabe S, Teramoto N, Nonaka Y, Watabe H, Imabayashi E, Ohta Y, Jino H, Ejima N, Sawada T, Iida H, Matsuda H, Ugawa Y. Long-term effect of motor cortical repetitive transcranial magnetic stimulation. Ann Neurol. 2004;56(1):77–85.


18. Nonaka Y, Hayashi T, Ohnishi T, Okabe S, Teramoto N, Ueno S, Watabe H, Matsuda H, Iida H, Ugawa Y. A coil for magnetic stimulation of the macaque monkey brain. Suppl Clin Neurophysiol. 2003;56:75–80.

17. Iida H, Hayashi T, Eberl S, Saji H. Quantification in SPECT cardiac imaging. J Nucl Med. 2003;44(1):40–2.

16. Hayashi T, Watabe H, Kudomi N, Kim KM, Enmi J, Hayashida K, Iida H. A theoretical model of oxygen delivery and metabolism for physiologic interpretation of quantitative cerebral blood flow and metabolic rate of oxygen. J Cereb Blood Flow Metab. 2003;23(11):1314–23.

15. Shidahara M, Watabe H, Kim K, Hachiya T, Sayama I, Kanno I, Iida H. Impact of attenuation and scatter correction in SPECT for Quantification of cerebral blood flow using 99mTc-Ethyl cystenate dimer. IEEE Trans Nucl Sci. 2002;49:5–11.

14. Shidahara M, Watabe H, Kim KM, Oka H, Sago M, Hayashi T, Miyake Y, Ishida Y, Hayashida K, Nakamura T, Iida H. Evaluation of a commercial PET tomograph-based system for the quantitative assessment of rCBF, rOEF and rCMRO2 by using sequential administration of 15O-labeled compounds. Ann Nucl Med. 2002;16(5):317–27.

13. Oyanagi C, Katsumi Y, Hanakawa T, Hayashi T, Thuy DD, Hashikawa K, Nagahama Y, Fukuyama H, Shibasaki H. Comparison of striatal dopamine D2 receptors in Parkinson’s disease and progressive supranuclear palsy patients using [123I] iodobenzofuran single-photon emission computed tomography. J Neuroimaging. 2002;12(4):316–24.

12. Hayashi T, Katsumi Y, Mukai T, Inoue M, Nagahama Y, Oyanagi C, Yamauchi H, Shibasaki H, Fukuyama H. Neuronal nitric oxide has a role as a perfusion regulator and a synaptic modulator in cerebellum but not in neocortex during somatosensory stimulation--an animal PET study. Neurosci Res. 2002;44(2):155–65.

11. Nagahama Y, Okada T, Katsumi Y, Hayashi T, Yamauchi H, Oyanagi C, Konishi J, Fukuyama H, Shibasaki H. Dissociable mechanisms of attentional control within the human prefrontal cortex. Cereb Cortex. 2001;11(1):85–92.

10. Yamauchi H, Fukuyama H, Nagahama Y, Katsumi Y, Hayashi T, Oyanagi C, Konishi J, Shio H. Comparison of the pattern of atrophy of the corpus callosum in frontotemporal dementia, progressive supranuclear palsy, and Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2000;69(5):623–9.

9. Katsumi Y, Hayashi T, Oyanagi C, Nagahama Y, Yamauchi H, Ono S, Fukuyama H, Shibasaki H. Glucose metabolism in the rat frontal cortex recovered without the recovery of choline acetyltransferase activity after lesioning of the nucleus basalis magnocellularis. Neurosci Lett. 2000;280(1):9–12.

8. Yamauchi H, Fukuyama H, Nagahama Y, Katsumi Y, Hayashi T, Okazawa H, Yonekura Y. Selective cerebral hematocrit decrease in the centrum semiovale after carotid artery occlusion: a PET study. J Cereb Blood Flow Metab. 1999;19(1):109–14.

7. Nagahama Y, Okada T, Katsumi Y, Hayashi T, Yamauchi H, Sawamoto N, Toma K, Nakamura K, Hanakawa T, Konishi J, Fukuyama H, Shibasaki H. Transient neural activity in the medial superior frontal gyrus and precuneus time locked with attention shift between object features. Neuroimage. 1999;10(2):193–9.

6. Katsumi Y, Hanakawa T, Fukuyama H, Hayashi T, Nagahama Y, Yamauchi H, Ouchi Y, Tsukada H, Shibasaki H. The effect of sequential lesioning in the basal forebrain on cerebral cortical glucose metabolism in rats. An animal positron emission tomography study. Brain Res. 1999;837(1-2):75–82.

5. Hayashi T, Fukuyama H, Katsumi Y, Hanakawa T, Nagahama Y, Yamauchi H, Tsukada H, Shibasaki H. Cerebral glucose metabolism in unilateral entorhinal cortex-lesioned rats: an animal PET study. Neuroreport. 1999;10(10):2113–8.

4. Hanakawa T, Katsumi Y, Fukuyama H, Honda M, Hayashi T, Kimura J, Shibasaki H. Mechanisms underlying gait disturbance in Parkinson’s disease: a single photon emission computed tomography study. Brain. 1999;122 ( Pt 7):1271–82.

3. Yamauchi H, Fukuyama H, Nagahama Y, Katsumi Y, Dong Y, Hayashi T, Konishi J, Kimura J. Atrophy of the corpus callosum, cortical hypometabolism, and cognitive impairment in corticobasal degeneration. Arch Neurol. 1998;55(5):609–14.

2. Nagahama Y, Sadato N, Yamauchi H, Katsumi Y, Hayashi T, Fukuyama H, Kimura J, Shibasaki H, Yonekura Y. Neural activity during attention shifts between object features. Neuroreport. 1998;9(11):2633–8.

1. Fukuyama H, Hayashi T, Katsumi Y, Tsukada H, Shibasaki H. Issues in measuring glucose metabolism of rat brain using PET: the effect of harderian glands on the frontal lobe. Neurosci Lett. 1998;255(2):99–102.

著書 Books:

1. Quantitation in Biomedical Imaging with PET and MRI (Iida H, Shah N, Hayashi T, eds), 2004, Amsterdam: Elsevier Science

著書節 Book sections:

1. Iida H, Hayashi T, Watabe H. (2001) Quantitative assessment of CBF and CMRO2 using PET. In: Neuroenegetics: relevance for functional brain imaging (Frackowiak RJ, Magistretti PJ, Shulman RG et al., eds), Strasbourg: Human Frontier Science Program, pp 71-81

2. Hayashi T, Katsumi Y, Inoue M, Nagahama Y, Oyanagi C, Yamauchi H, Fukuyama H, Shibasaki H. (2002) The role of neuronal nitric oxide in the regional neurovascular coupling. Voxel-based comparison between perfusion and metabolic PET images. In: Brain Activation and CBF control (Tomita M, Kanno I, Hamel E, eds), Amsterdam: Elsevier Science, pp 197-204

3. Hayashi T. (2004) Therapeutic mechanism of repetitive transcranial magnetic stimulation. In: Molecular Imaging with PET (Tamaki K, ed), Amsterdam: Elsevier Science

4. Hayashi T. (2004) The relationship of cerebral blood flow and oxygen metabolism revealed by effective oxygen diffusibility revealed by PET. In: Quantitation in Biomedical Imaging with PET and MRI (Iida H, Shah N, Hayashi T, eds), Amsterdam: Elsevier Science

テクニカルノート Technical note:

TN13-01. 林 拓也 喫煙欲求と自己制御の神経機構 Neural mechanism of cigarette craving and self-control.  <PDF>